PROTAC
25 Aug 2020
Proteolysis targeting chimeric molecules (PROTACs) are heterobifunctional small molecules with three chemical elements: a ligand binding to a target protein, a ligand binding to E3 ubiquitin ligase, and a linker for conjugating these two ligands. One of the small molecule ligands is designed to bind a disease target protein in the cell whilst the other binds with high affinity to an E3 ligase.
CRISPR
17 Nov 2020
Gene editing, a group of technologies that give scientists the ability to change an organism's DNA, is of vital importance in cell and gene therapy. CRISPR is a revolutionary gene editing technology which has become the hottest research tool in the field of biological sciences in just a few years since its introduction in 2012. However, people may still wonder if there are any other types of gene editing technologies.
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